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| League History Index | Players | Teams | Managers | Leagues | Leaderboards | Awards | Accomplishments |
| Rank | Player | ERA | YEAR | Open Postseason Leaderboard |
|---|---|---|---|---|
| 1 | José Piñeda# | 0.243 | 1905-1908 | |
| 2 | René Gálvez# | 0.287 | 1906-1908 | |
| 3 | Fernando Lara# | 0.614 | 1904-1907 | |
| 4 | Rafael Arriola# | 1.465 | 1906-1908 | |
| 5 | Damián Canchola# | 1.543 | 1901-1905 | |
| 6 | Salomón Portillo# | 1.636 | 1901-1908 | |
| 7 | Bert Cook# | 1.642 | 1903-1908 | |
| 8 | Gerardo Pérez# | 1.800 | 1905-1908 | |
| 9 | Leoncio Landeros# | 1.851 | 1901-1908 | |
| 10 | Senén Tavárez# | 1.853 | 1901-1908 | |
| 11 | Bienvenido Quiñones# | 1.857 | 1901-1908 | |
| 12 | Francisco Martínez# | 1.957 | 1902-1908 | |
| 13 | Jesús Montiel# | 1.967 | 1901-1908 | |
| 14 | Jairo Canseco# | 1.973 | 1902-1908 | |
| 15 | Pedro Rodríguez# | 1.988 | 1901-1908 | |
| 16 | Santiago Carriel# | 1.996 | 1901-1908 | |
| 17 | Gabriel Camarillo# | 2.143 | 1903-1908 | |
| 18 | Bolívar Gallegos# | 2.236 | 1905-1905 | |
| 19 | Hernán Navarrete# | 2.269 | 1904-1908 | |
| 20 | Conrado Chaidez# | 2.274 | 1901-1908 | |
| 21 | Germán Medina# | 2.298 | 1904-1908 | |
| 22 | Omar Murcia# | 2.422 | 1901-1906 | |
| 23 | Adelmo Almeida# | 2.477 | 1904-1908 | |
| 24 | Rodrigo Martínez# | 2.492 | 1904-1908 | |
| 25 | Roodan Keay | 2.551 | 1901-1907 | |
| 26 | Jorge Castro# | 2.571 | 1901-1908 | |
| 27 | José Martínez | 2.585 | 1901-1904 | |
| 28 | Crisóstomo López# | 2.600 | 1902-1908 | |
| 29 | Leucipo Hernández# | 2.607 | 1902-1908 | |
| 30 | Leovigildo Méndez# | 2.663 | 1903-1906 | |
| 31 | Ricardo Pérez | 2.727 | 1901-1907 | |
| 31 | Alberto Torres# | 2.727 | 1902-1908 | |
| 33 | Agamenón Musco# | 2.767 | 1906-1908 | |
| 34 | Benjamín Cedillo# | 2.769 | 1904-1908 | |
| 35 | Telémaco Rodríguez# | 2.795 | 1901-1908 | |
| 36 | Mateo Longoria | 2.807 | 1901-1905 | |
| 37 | Santiago Márquez# | 2.872 | 1903-1908 | |
| 38 | Amílcar Bravo# | 2.919 | 1906-1908 | |
| 39 | Aldo Escobar# | 2.937 | 1902-1907 | |
| 40 | Lorenzo Flores | 2.953 | 1901-1905 | |
| 41 | Joe White# | 3.073 | 1906-1908 | |
| 42 | Miguel Núñez | 3.086 | 1901-1905 | |
| 43 | Alonso Rivera | 3.106 | 1901-1904 | |
| 44 | Pascual Gallegos# | 3.147 | 1901-1908 | |
| 45 | José Chora# | 3.163 | 1904-1908 | |
| 46 | Adán Acosta# | 3.321 | 1901-1908 | |
| 47 | Abdón Martínez# | 3.329 | 1906-1908 | |
| 48 | Ricardo Espinosa# | 3.447 | 1905-1908 | |
| 49 | Édgar García | 3.475 | 1901-1906 | |
| 50 | Práxedes Valenzuela# | 3.477 | 1904-1907 | |
| 51 | Pascual Ramírez# | 3.570 | 1902-1907 | |
| 52 | Ignacio Rodríguez# | 3.649 | 1901-1908 | |
| 53 | Sansón Contreras# | 3.767 | 1901-1908 | |
| 54 | Diego Salas# | 4.219 | 1902-1906 | |
| 55 | Raimundo Magaña# | 4.772 | 1905-1908 | |
| 56 | Juan Cartagena | 5.289 | 1901-1905 | |
| 57 | Carlos Loza# | 5.657 | 1902-1907 |
