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| League History Index | Players | Teams | Managers | Leagues | Leaderboards | Awards | Accomplishments |
| Rank | Player | ERA | YEAR | Open Postseason Career Leaderboard |
|---|---|---|---|---|
| 1 | Jesús Castellón# | 0.675 | 1913 | |
| 2 | Alrigo Leitez# | 0.931 | 1912 | |
| 3 | Darnell Wilson | 1.000 | 1913 | |
| 3 | Roberto Romero | 1.000 | 1902 | |
| 5 | Teócrito Salinas | 1.059 | 1903 | |
| 6 | Apolonio Ruiz | 1.239 | 1902 | |
| 7 | Dean Kerfoot | 1.256 | 1901 | |
| 8 | Andrónico Lona | 1.333 | 1907 | |
| 9 | Pelayo Fernández# | 1.500 | 1914 | |
| 10 | Hernán Gutiérrez# | 1.521 | 1910 | |
| 11 | Nicolás Lerma | 1.558 | 1907 | |
| 12 | Francisco Lerma | 1.565 | 1902 | |
| 13 | Andrónico Lona | 1.588 | 1910 | |
| 13 | Donnie Lynch# | 1.588 | 1913 | |
| 15 | Teócrito Salinas | 1.653 | 1909 | |
| 16 | Trevor Lindsay | 1.667 | 1902 | |
| 17 | Manuel Martínez# | 1.688 | 1906 | |
| 18 | Luis Fernández# | 1.766 | 1911 | |
| 19 | Harland Vaillancourt | 1.929 | 1907 | |
| 20 | Telémaco Aquino# | 2.015 | 1906 | |
| 21 | Don Day | 2.057 | 1913 | |
| 22 | Gumersindo Rodríguez# | 2.077 | 1907 | |
| 22 | Seiju Yamasaki | 2.077 | 1914 | |
| 24 | Lucas Galindo | 2.118 | 1903 | |
| 24 | Telémaco Aquino# | 2.118 | 1910 | |
| 26 | Jeremy Zinck | 2.250 | 1904 | |
| 26 | Lisandro Acevedo# | 2.250 | 1911 | |
| 28 | Efraín Jurado# | 2.314 | 1909 | |
| 29 | Oliverio Rohena# | 2.333 | 1908 | |
| 29 | Santiago Romero | 2.333 | 1905 | |
| 29 | Don Day | 2.333 | 1912 | |
| 32 | Paul Keys | 2.423 | 1904 | |
| 33 | Hernán Ortiz | 2.455 | 1901 | |
| 34 | Gumersindo Rodríguez# | 2.489 | 1904 | |
| 35 | Luis Aguilar# | 2.500 | 1912 | |
| 36 | Príamo Díaz | 2.520 | 1913 | |
| 37 | Víctor Gutiérrez# | 2.547 | 1912 | |
| 37 | Ed Townsend | 2.547 | 1912 | |
| 39 | Idriss Bonnefoy | 2.554 | 1901 | |
| 40 | Alvin Stamp | 2.750 | 1904 | |
| 40 | Jon Schofield | 2.750 | 1903 | |
| 42 | Paul Keys | 2.769 | 1901 | |
| 43 | Apolonio Ruiz | 2.812 | 1903 | |
| 43 | Lorenzo Álvarez | 2.812 | 1905 | |
| 45 | Jordan Turnbull | 2.821 | 1903 | |
| 46 | Lisandro Acevedo# | 2.842 | 1906 | |
| 47 | Hernán Gutiérrez# | 2.864 | 1911 | |
| 47 | Celino Zambrano# | 2.864 | 1912 | |
| 49 | Dan Cartier | 2.872 | 1914 | |
| 50 | Matt Kirby | 2.935 | 1905 | |
| 51 | Greg McIlmoyle | 2.963 | 1901 | |
| 52 | Santiago Romero | 3.000 | 1906 | |
| 52 | Eduardo Ayala | 3.000 | 1909 | |
| 52 | Daniel Florentino | 3.000 | 1903 | |
| 55 | Lorenzo Álvarez | 3.057 | 1911 | |
| 56 | Steve Noonan# | 3.076 | 1913 | |
| 57 | Eduardo Ayala | 3.115 | 1906 | |
| 57 | Édgar Martínez# | 3.115 | 1907 | |
| 59 | Tobías García | 3.191 | 1903 | |
| 60 | Gumersindo Rodríguez# | 3.240 | 1905 | |
| 61 | Lucas Galindo | 3.316 | 1908 | |
| 62 | Príamo Díaz | 3.340 | 1912 | |
| 63 | Édgar Martínez# | 3.375 | 1909 | |
| 63 | Tony Renny | 3.375 | 1911 | |
| 63 | Celino Zambrano# | 3.375 | 1913 | |
| 66 | Lorenzo Álvarez | 3.441 | 1904 | |
| 67 | Lucas Galindo | 3.484 | 1902 | |
| 68 | Lorenzo Álvarez | 3.500 | 1907 | |
| 69 | Nicolás Lerma | 3.522 | 1909 | |
| 70 | Telémaco Aquino# | 3.566 | 1908 | |
| 71 | Telémaco Aquino# | 3.600 | 1911 | |
| 72 | Efraín Jurado# | 3.635 | 1908 | |
| 73 | Efraín Jurado# | 3.649 | 1906 | |
| 74 | Corey Lang | 3.706 | 1904 | |
| 75 | Andrónico Lona | 3.734 | 1909 | |
| 76 | Telémaco García | 3.789 | 1902 | |
| 76 | Bashir Royma# | 3.789 | 1909 | |
| 78 | Ken Crabbe | 3.808 | 1904 | |
| 79 | Telémaco Aquino# | 3.857 | 1905 | |
| 80 | Roberto Quevedo# | 3.960 | 1911 | |
| 81 | Felipe Camarillo | 4.000 | 1905 | |
| 81 | Ed Townsend | 4.000 | 1902 | |
| 83 | Iapeto Martínez# | 4.154 | 1904 | |
| 84 | Matt Kirby | 4.235 | 1906 | |
| 84 | Lorenzo Álvarez | 4.235 | 1910 | |
| 86 | Efraín Jurado# | 4.286 | 1905 | |
| 87 | Gabriel Gutiérrez | 4.368 | 1908 | |
| 88 | Anatolio Aguillón | 4.378 | 1909 | |
| 89 | Craig McGaughey | 4.438 | 1901 | |
| 90 | Ernesto Lemus | 4.500 | 1912 | |
| 90 | Newton Ashe | 4.500 | 1902 | |
| 92 | Eduardo Ayala | 4.596 | 1905 | |
| 93 | Santiago Romero | 4.610 | 1903 | |
| 94 | Nicolás Lerma | 4.680 | 1910 | |
| 95 | Álvaro Loredo | 4.860 | 1903 | |
| 96 | Édgar Martínez# | 5.182 | 1910 | |
| 97 | Miguel Acevedo | 5.260 | 1905 | |
| 98 | Federico Moya | 5.548 | 1908 | |
| 99 | Lisandro Acevedo# | 5.645 | 1903 | |
| 100 | Fulco Quiñones# | 5.764 | 1913 |
