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| League History Index | Players | Teams | Managers | Leagues | Leaderboards | Awards | Accomplishments |
| Rank | Player | ERA | YEAR | Open Career Leaderboard |
|---|---|---|---|---|
| 1 | Florentino Cruz# | 1.280 | 1906 | |
| 2 | Martín Torres# | 1.288 | 1906 | |
| 3 | Effie Norton | 1.319 | 1905 | |
| 4 | Amadeo Jiménez# | 1.322 | 1905 | |
| 5 | Jason Gunter# | 1.323 | 1905 | |
| 6 | Ross Best# | 1.366 | 1906 | |
| 7 | George Brady# | 1.406 | 1906 | |
| 8 | Frank Harrison# | 1.411 | 1906 | |
| 9 | Hiram Sierra# | 1.423 | 1905 | |
| 10 | Tony Schmidt | 1.427 | 1905 | |
| 11 | Ryan Gregory | 1.435 | 1904 | |
| 12 | Bill Blair | 1.442 | 1905 | |
| 13 | Donnie Williams# | 1.451 | 1905 | |
| 14 | Marco Ríos | 1.495 | 1905 | |
| 15 | Marco Ríos | 1.500 | 1906 | |
| 16 | Bob Cashmann | 1.524 | 1905 | |
| 17 | Brandon Brown | 1.535 | 1906 | |
| 18 | Matt Francis | 1.549 | 1906 | |
| 19 | Gerardo Domínguez | 1.557 | 1905 | |
| 20 | Rich Tucker | 1.561 | 1906 | |
| 21 | Bill Phyle# | 1.571 | 1904 | |
| 22 | George Brady# | 1.574 | 1905 | |
| 23 | Federico Mireles# | 1.579 | 1906 | |
| 24 | Gerardo Domínguez | 1.581 | 1904 | |
| 25 | Danny Maxwell# | 1.585 | 1905 | |
| 26 | Stewart Hunter | 1.586 | 1906 | |
| 27 | Agustín Acosta# | 1.602 | 1904 | |
| 28 | Silvio Ramírez | 1.607 | 1906 | |
| 29 | Jack Stivetts | 1.609 | 1905 | |
| 30 | Damian Freake | 1.617 | 1906 | |
| 31 | Josh Shields# | 1.633 | 1905 | |
| 31 | Gus Dorner | 1.633 | 1905 | |
| 33 | Effie Norton | 1.643 | 1906 | |
| 34 | Tom Moriarty | 1.651 | 1904 | |
| 35 | James McMullin | 1.660 | 1904 | |
| 36 | Bob Cashmann | 1.668 | 1906 | |
| 36 | Rex Smith | 1.668 | 1905 | |
| 38 | José Arce# | 1.670 | 1905 | |
| 39 | Bert Cunningham | 1.675 | 1905 | |
| 40 | Brendan McDowell# | 1.676 | 1905 | |
| 41 | Jim Lent | 1.697 | 1906 | |
| 42 | Nick Andrews# | 1.700 | 1905 | |
| 43 | Luis Quiroz# | 1.701 | 1906 | |
| 44 | Gus Dorner | 1.703 | 1904 | |
| 45 | Andres Ortega# | 1.707 | 1905 | |
| 45 | Peter Terry# | 1.707 | 1905 | |
| 47 | Jake Glover | 1.711 | 1905 | |
| 48 | Benicio Reyes# | 1.712 | 1905 | |
| 49 | Brent Forsberg# | 1.714 | 1906 | |
| 50 | Aluino de Varona | 1.715 | 1904 | |
| 51 | Eusebio Ortiz# | 1.716 | 1907 | |
| 52 | Cole Gagnon | 1.717 | 1905 | |
| 53 | Cecilio Hernández | 1.725 | 1904 | |
| 54 | Reynaldo Ontiveros | 1.726 | 1905 | |
| 54 | Matt Francis | 1.726 | 1904 | |
| 56 | Hiram Sierra# | 1.732 | 1904 | |
| 57 | Brandon Brown | 1.733 | 1904 | |
| 58 | Federico Mireles# | 1.736 | 1905 | |
| 59 | Darío Domínguez# | 1.741 | 1906 | |
| 60 | Ian Cooper | 1.754 | 1905 | |
| 61 | Brandon Brown | 1.756 | 1905 | |
| 62 | Luis Solís | 1.757 | 1904 | |
| 63 | Hank Gastright | 1.761 | 1904 | |
| 64 | Cameron Gray | 1.764 | 1905 | |
| 65 | Édgar Bethancourt | 1.767 | 1904 | |
| 66 | Luis Solís | 1.785 | 1906 | |
| 67 | Pol Brennan# | 1.788 | 1906 | |
| 68 | Antonio Sánchez# | 1.789 | 1905 | |
| 69 | Aldomiro González# | 1.790 | 1905 | |
| 70 | Jack Pfiester | 1.800 | 1904 | |
| 71 | Beany Jacobson# | 1.805 | 1905 | |
| 72 | Chris Matthews | 1.806 | 1904 | |
| 73 | Frank Harrison# | 1.810 | 1905 | |
| 74 | Luis García# | 1.816 | 1906 | |
| 75 | F. Scott# | 1.826 | 1904 | |
| 76 | Hansel Núñez# | 1.827 | 1904 | |
| 77 | Esteban Martínez | 1.836 | 1904 | |
| 78 | Josh Cornaby# | 1.842 | 1905 | |
| 78 | Norm McIntyre | 1.842 | 1905 | |
| 80 | Báquides Pérez# | 1.857 | 1906 | |
| 81 | Rodrigo Padilla# | 1.859 | 1906 | |
| 82 | Ross Best# | 1.863 | 1904 | |
| 82 | Damian Freake | 1.863 | 1905 | |
| 84 | Agustín Acosta# | 1.865 | 1905 | |
| 85 | Rich Tucker | 1.866 | 1905 | |
| 86 | Ed Walsh# | 1.869 | 1905 | |
| 87 | Dave Vincent | 1.873 | 1905 | |
| 88 | Silvio Ramírez | 1.879 | 1905 | |
| 89 | Rich Crowley | 1.881 | 1905 | |
| 90 | Pablo Cortés# | 1.882 | 1905 | |
| 90 | Ian Cooper | 1.882 | 1904 | |
| 92 | Ed Walsh# | 1.884 | 1904 | |
| 93 | Agapito de la Rosa# | 1.885 | 1906 | |
| 94 | George Davies | 1.890 | 1906 | |
| 94 | Ed Beatin | 1.890 | 1905 | |
| 96 | Ben Lowe# | 1.894 | 1907 | |
| 97 | Jean Doucet | 1.898 | 1906 | |
| 98 | Steve Stewart# | 1.906 | 1906 | |
| 99 | Nerón Solano# | 1.911 | 1905 | |
| 99 | Mike Jones | 1.911 | 1905 |
