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| League History Index | Players | Teams | Managers | Leagues | Leaderboards | Awards | Accomplishments |
| Rank | Player | ERA | YEAR | Open Season Leaderboard |
|---|---|---|---|---|
| 1 | Esteban Martín# | 2.272 | 1906-1913 | |
| 2 | Fred Glenn | 2.369 | 1906-1915 | |
| 3 | Oscar Alanis | 2.385 | 1906-1909 | |
| 4 | Jonás Corona# | 2.597 | 1906-1915 | |
| 5 | Samuel Gámez# | 2.666 | 1906-1915 | |
| 6 | Alfie Fraser# | 2.752 | 1906-1915 | |
| 7 | Saturnín Castillo# | 2.870 | 1906-1915 | |
| 8 | Iapeto Martínez# | 2.904 | 1912-1915 | |
| 9 | Javier Vega# | 2.954 | 1906-1915 | |
| 10 | Rafael Valentín# | 2.956 | 1906-1915 | |
| 11 | Benicio Montano# | 3.012 | 1906-1911 | |
| 12 | Diomedes Vásquez | 3.022 | 1906-1909 | |
| 13 | Próspero Beltrán# | 3.024 | 1906-1915 | |
| 14 | Matías Torres# | 3.039 | 1906-1915 | |
| 15 | Uriel Gutierres# | 3.053 | 1906-1915 | |
| 16 | Eugenio Prieto# | 3.115 | 1911-1915 | |
| 17 | Patroclo Zaragoza# | 3.180 | 1906-1915 | |
| 18 | Luis Almodóvar# | 3.185 | 1906-1915 | |
| 19 | Aldomiro González# | 3.194 | 1912-1915 | |
| 20 | Ambrosio Artayett# | 3.212 | 1906-1914 | |
| 21 | Francisco González | 3.267 | 1906-1910 | |
| 22 | Eunice Engana# | 3.291 | 1906-1915 | |
| 22 | Rodulfo Moquete# | 3.291 | 1913-1915 | |
| 24 | Casimiro Ríos# | 3.305 | 1906-1914 | |
| 25 | Damián Canchola | 3.310 | 1906-1911 | |
| 26 | Ramón Escalante# | 3.316 | 1906-1915 | |
| 27 | Osvaldo Loera# | 3.321 | 1910-1915 | |
| 28 | Cody Deakin | 3.334 | 1906-1910 | |
| 29 | Rutilio Romero# | 3.335 | 1906-1911 | |
| 30 | Shaun McKinnon | 3.345 | 1906-1915 | |
| 31 | Medardo Crosby# | 3.365 | 1906-1915 | |
| 32 | Samuel Gómez# | 3.370 | 1906-1914 | |
| 33 | Eugenio Núñez# | 3.371 | 1906-1915 | |
| 34 | Ferdinando Osuna# | 3.374 | 1906-1915 | |
| 35 | Tarquino Hernández | 3.383 | 1906-1912 | |
| 36 | Julián Pérez | 3.387 | 1906-1911 | |
| 37 | Florentino Cruz# | 3.395 | 1909-1915 | |
| 38 | Konan Wray | 3.398 | 1906-1915 | |
| 39 | Víctor Hugo García# | 3.404 | 1906-1915 | |
| 40 | Rosendo del Toro# | 3.418 | 1906-1915 | |
| 41 | Reginaldo Alonso# | 3.446 | 1906-1915 | |
| 42 | Cayetano Mendoza# | 3.473 | 1906-1915 | |
| 43 | Canice Gray# | 3.478 | 1906-1915 | |
| 43 | Pero Sogliano# | 3.478 | 1906-1915 | |
| 45 | Raúl Muñoz# | 3.481 | 1908-1915 | |
| 46 | Marco Maldonado# | 3.483 | 1906-1915 | |
| 47 | Ramón Rodríguez# | 3.484 | 1906-1914 | |
| 48 | José Flores# | 3.497 | 1906-1915 | |
| 49 | Fernando Mascorro# | 3.502 | 1906-1915 | |
| 50 | Hans Bernardino# | 3.511 | 1906-1915 | |
| 51 | Esteban Delgado# | 3.536 | 1906-1915 | |
| 52 | Gustavo Cano# | 3.538 | 1906-1912 | |
| 53 | Julio Berrones# | 3.541 | 1907-1915 | |
| 54 | Disibodo Bermúdez# | 3.553 | 1906-1915 | |
| 55 | Enrique Ortiz# | 3.564 | 1906-1915 | |
| 56 | Zacarías Nájera# | 3.567 | 1906-1915 | |
| 57 | Mateus Balieiro# | 3.571 | 1906-1915 | |
| 58 | Gualter Firmino# | 3.572 | 1906-1915 | |
| 59 | Quilvio González# | 3.594 | 1906-1915 | |
| 60 | Tomás Ruiz# | 3.595 | 1906-1915 | |
| 61 | Martín Martínez# | 3.600 | 1906-1915 | |
| 62 | Baltasar Saldaña | 3.612 | 1907-1909 | |
| 63 | Baldovino Santillán# | 3.630 | 1906-1915 | |
| 64 | Pedro Saiz# | 3.644 | 1906-1915 | |
| 65 | Eliezer Rivera# | 3.651 | 1906-1915 | |
| 66 | Richard Barrow | 3.659 | 1910-1915 | |
| 67 | Samuel Marshall | 3.683 | 1906-1915 | |
| 67 | Juan Larios | 3.683 | 1906-1909 | |
| 69 | Gilberto López# | 3.684 | 1906-1915 | |
| 70 | Philippe Maire# | 3.689 | 1906-1915 | |
| 71 | Curcio Arana# | 3.692 | 1906-1914 | |
| 72 | Enrico Miegge# | 3.706 | 1906-1915 | |
| 73 | Ramón Lenz# | 3.715 | 1906-1915 | |
| 74 | Bryan Robinson | 3.729 | 1907-1915 | |
| 75 | Gabriel Quesada# | 3.740 | 1908-1915 | |
| 76 | Práxedes Vega# | 3.749 | 1906-1915 | |
| 77 | Garrett Colgan | 3.760 | 1906-1914 | |
| 78 | Rodulfo Vega# | 3.765 | 1906-1915 | |
| 79 | Hércules Serafín# | 3.778 | 1909-1915 | |
| 80 | Víctor Coronado | 3.797 | 1907-1912 | |
| 81 | Javier Rodríguez# | 3.801 | 1906-1915 | |
| 82 | Marcos Villaseñor# | 3.804 | 1906-1913 | |
| 83 | Gerardo Solís | 3.805 | 1906-1912 | |
| 84 | Lisandro Herrera# | 3.810 | 1908-1915 | |
| 85 | Alfonso Nava# | 3.820 | 1906-1915 | |
| 86 | Humberto Camarillo# | 3.855 | 1908-1915 | |
| 87 | Fulco García# | 3.857 | 1906-1915 | |
| 88 | José Shaefer# | 3.866 | 1907-1915 | |
| 89 | Pablo Mármol# | 3.879 | 1906-1915 | |
| 90 | Gedeón Martínez# | 3.888 | 1906-1915 | |
| 90 | Rafael Ramón# | 3.888 | 1910-1915 | |
| 92 | Luis Martínez# | 3.899 | 1911-1915 | |
| 93 | Matthew Bunge# | 3.903 | 1911-1915 | |
| 94 | Ramón Valentín# | 3.962 | 1906-1915 | |
| 95 | Guignard Romanelli# | 3.989 | 1906-1915 | |
| 96 | Esteban Rodríguez# | 3.990 | 1906-1915 | |
| 96 | Efraín Cisneros# | 3.990 | 1907-1915 | |
| 98 | Higinio Estrada# | 4.016 | 1914-1915 | |
| 99 | Esteban Rivera | 4.023 | 1907-1912 | |
| 100 | Raúl Santiago# | 4.088 | 1908-1915 |
