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| League History Index | Players | Teams | Managers | Leagues | Leaderboards | Awards | Accomplishments |
| Rank | Player | HR | YEAR | Open Postseason Leaderboard |
|---|---|---|---|---|
| 1 | Diego Sánchez# | 14 | 1902-1915 | |
| 2 | Armando Rodríguez# | 12 | 1902-1915 | |
| 2 | Arjun Vipperla# | 12 | 1902-1915 | |
| 4 | Alberto Lozano# | 10 | 1903-1915 | |
| 5 | Ted Balloon# | 9 | 1901-1915 | |
| 5 | René Calva# | 9 | 1904-1915 | |
| 5 | Lennon Robertson# | 9 | 1903-1915 | |
| 5 | Ezequiel Vásquez# | 9 | 1903-1915 | |
| 9 | Eunosto Gutiérrez# | 8 | 1902-1915 | |
| 10 | Semónides Cataño# | 7 | 1910-1915 | |
| 10 | Manuel Cortés# | 7 | 1903-1915 | |
| 10 | Rafael García# | 7 | 1903-1915 | |
| 13 | Ben Browne# | 6 | 1908-1915 | |
| 13 | Luis Flores# | 6 | 1903-1915 | |
| 13 | Ignacio Lozano# | 6 | 1903-1915 | |
| 13 | Luis Piñero# | 6 | 1903-1915 | |
| 13 | Curro Terrazas# | 6 | 1903-1915 | |
| 18 | Carmelo Castillo# | 5 | 1903-1915 | |
| 18 | Luis Castro# | 5 | 1903-1915 | |
| 18 | Rubén Meza# | 5 | 1904-1915 | |
| 18 | Carter Pattullo | 5 | 1901-1903 | |
| 18 | Eduino Rizo# | 5 | 1905-1915 | |
| 18 | Bashir Royma# | 5 | 1901-1915 | |
| 18 | Avelino Saldívar# | 5 | 1905-1915 | |
| 25 | Nicodemo Caballero# | 4 | 1904-1915 | |
| 25 | Jeremías Cabrera# | 4 | 1903-1915 | |
| 25 | Eulalio Castillo# | 4 | 1903-1915 | |
| 25 | Adriel Cisneros# | 4 | 1905-1915 | |
| 25 | Héctor Delgado# | 4 | 1903-1915 | |
| 25 | Hortensio Galicia# | 4 | 1904-1915 | |
| 25 | Pascual García# | 4 | 1912-1915 | |
| 25 | Virgilio González# | 4 | 1904-1914 | |
| 25 | Hayuya Marqués# | 4 | 1907-1915 | |
| 25 | Feliciano Marín# | 4 | 1904-1915 | |
| 25 | Marcelo Moreno# | 4 | 1903-1915 | |
| 25 | Carlos Ortiz# | 4 | 1905-1915 | |
| 25 | Gabriel Palacios# | 4 | 1910-1915 | |
| 25 | Plácido Polanco# | 4 | 1902-1915 | |
| 25 | Nehemías Ruiz# | 4 | 1902-1908 | |
| 25 | Domingo Santamaría# | 4 | 1902-1915 | |
| 25 | Orestes Solano# | 4 | 1906-1915 | |
| 25 | Fausto Souza# | 4 | 1905-1915 | |
| 25 | Tomás Sánchez# | 4 | 1904-1915 | |
| 25 | Cirilo Villagrán | 4 | 1901-1902 | |
| 25 | Fintan Whelan# | 4 | 1906-1915 | |
| 46 | Zenón Alvarado# | 3 | 1904-1915 | |
| 46 | Leonel Alvarrán# | 3 | 1903-1915 | |
| 46 | Ciriaco Bartra# | 3 | 1902-1915 | |
| 46 | Charles Bender# | 3 | 1911-1914 | |
| 46 | Anatolio Castellanos# | 3 | 1906-1915 | |
| 46 | Sarpedón Castillo | 3 | 1901-1902 | |
| 46 | Marco Colón# | 3 | 1903-1915 | |
| 46 | Mario Cordero# | 3 | 1903-1915 | |
| 46 | Gustavo Dávalos# | 3 | 1905-1915 | |
| 46 | Leví Esparza# | 3 | 1905-1915 | |
| 46 | Fernando Fontánez# | 3 | 1905-1915 | |
| 46 | Basilio Gallegos | 3 | 1901-1912 | |
| 46 | Gaspar García# | 3 | 1904-1915 | |
| 46 | Dane Grant | 3 | 1901-1909 | |
| 46 | José Guerra | 3 | 1902-1914 | |
| 46 | José Guzmán# | 3 | 1902-1915 | |
| 46 | Ewan Mackenzie | 3 | 1901-1915 | |
| 46 | Greg McAlister | 3 | 1901-1904 | |
| 46 | Jesús Monge# | 3 | 1903-1915 | |
| 46 | Ángel Moreno# | 3 | 1911-1915 | |
| 46 | Felipe Munguía# | 3 | 1904-1915 | |
| 46 | Ray Neale | 3 | 1901-1902 | |
| 46 | Keane O'Sullivan# | 3 | 1904-1915 | |
| 46 | Enrique Ocampo# | 3 | 1913-1915 | |
| 46 | Guillermo Rivera# | 3 | 1904-1915 | |
| 46 | Marcos Solís# | 3 | 1907-1915 | |
| 46 | Daniel Sánchez | 3 | 1901-1902 | |
| 46 | Anselmo Trujillo | 3 | 1901-1904 | |
| 46 | Federico Urtiaga# | 3 | 1904-1915 | |
| 46 | Herminio Vargas# | 3 | 1910-1915 | |
| 46 | José Villa# | 3 | 1904-1915 | |
| 46 | Samuel Vásquez# | 3 | 1904-1915 | |
| 78 | Sansón Apaez# | 2 | 1906-1915 | |
| 78 | Faustino Aragón# | 2 | 1907-1915 | |
| 78 | Mike Bellenger | 2 | 1901-1909 | |
| 78 | Alberto Benítez# | 2 | 1902-1915 | |
| 78 | Enrique Caballero# | 2 | 1904-1909 | |
| 78 | Efraín Calderón# | 2 | 1903-1915 | |
| 78 | Benjamín Centeno# | 2 | 1902-1915 | |
| 78 | Patrick Chauvet | 2 | 1901-1902 | |
| 78 | Ramón Chávez# | 2 | 1903-1915 | |
| 78 | Luis Delgado# | 2 | 1902-1914 | |
| 78 | Ricardo Dávalos# | 2 | 1903-1915 | |
| 78 | Renato Díaz# | 2 | 1903-1915 | |
| 78 | Ildefonso Espinoza# | 2 | 1903-1915 | |
| 78 | Eugenio Franco# | 2 | 1902-1915 | |
| 78 | Fulgencio García# | 2 | 1906-1915 | |
| 78 | Miguel García# | 2 | 1904-1915 | |
| 78 | Pablo García# | 2 | 1903-1915 | |
| 78 | Alberto Garfias# | 2 | 1902-1910 | |
| 78 | Nuño González# | 2 | 1902-1915 | |
| 78 | Galeno Henríquez# | 2 | 1903-1915 | |
| 78 | Kieron Lock | 2 | 1915-1915 | |
| 78 | Alfonso Luján# | 2 | 1904-1915 | |
| 78 | Hansel Macías# | 2 | 1906-1915 |
